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Rapid emergence of transmissible SARS-CoV-2 variants in mild community cases (preprint)
Michael Andrew Crone; Seran Hakki; Jie Zhou; Carolina Rosadas de Oliveira; Kieran J Madon; Aleksandra V Koycheva; Anjna Badhan; Jakob Jonnerby; Joe Fenn; Rhia Kundu; Jack L Barnett; Sean Nevin; Emily Conibear; Nieves Derqui-Fernandez; Timesh D Pillay; Robert Varro; Constanta Luca; Valerie Quinn; Ahmad Shazaad; Maria Zambon; Wendy Barclay; Jake Dunning; Paul S Freemont; Graham P Taylor; Ajit Lalvani.
medrxiv; 2023.
Preprint in English | medRxiv | ID: ppzbmed-10.1101.2023.02.15.23285923

ABSTRACT

SARS-CoV-2 immune-escape variants have only been observed to arise in immunosuppressed COVID-19 cases, during prolonged viral shedding. Through daily longitudinal RT-qPCR, quantitative viral culture and sequencing, we observe for the first time the evolution of transmissible variants harbouring mutations consistent with immune-escape in mild community cases within 2 weeks of infection.


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COVID-19
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